Datasets:

HiTZ
/

Multilingual-BioASQ-6B

id stringlengths 24 24	type stringclasses 4 values	body stringlengths 13 215	ideal_answer sequencelengths 1 12	exact_answer sequencelengths 0 44	snippets sequencelengths 0 121	documents sequencelengths 1 157	triples listlengths 0 537	concepts sequencelengths 0 99
55031181e9bde69634000014	summary	Is Hirschsprung disease a mendelian or a multifactorial disorder?	[ "Coding sequence mutations in RET, GDNF, EDNRB, EDN3, and SOX10 are involved in the development of Hirschsprung disease. The majority of these genes was shown to be related to Mendelian syndromic forms of Hirschsprung's disease, whereas the non-Mendelian inheritance of sporadic non-syndromic Hirschsprung disease pr...	[]	[ "Hirschsprung disease (HSCR) is a multifactorial, non-mendelian disorder in which rare high-penetrance coding sequence mutations in the receptor tyrosine kinase RET contribute to risk in combination with mutations at other genes", "In this study, we review the identification of genes and loci involved in the non-...	[ "http://www.ncbi.nlm.nih.gov/pubmed/15829955", "http://www.ncbi.nlm.nih.gov/pubmed/6650562", "http://www.ncbi.nlm.nih.gov/pubmed/12239580", "http://www.ncbi.nlm.nih.gov/pubmed/21995290", "http://www.ncbi.nlm.nih.gov/pubmed/23001136", "http://www.ncbi.nlm.nih.gov/pubmed/15617541", "http://www.ncbi.nlm.ni...	[]	[ "http://www.disease-ontology.org/api/metadata/DOID:10487", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006627", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020412", "http://www.disease-ontology.org/api/metadata/DOID:11372" ]
55046d5ff8aee20f27000007	list	List signaling molecules (ligands) that interact with the receptor EGFR?	[ "The 7 known EGFR ligands are: epidermal growth factor (EGF), betacellulin (BTC), epiregulin (EPR), heparin-binding EGF (HB-EGF), transforming growth factor-α [TGF-α], amphiregulin (AREG) and epigen (EPG)." ]	[ "epidermal growth factor", "betacellulin", "epiregulin", "heparin-binding epidermal growth factor", "transforming growth factor-α", "amphiregulin", "epigen" ]	[ "the epidermal growth factor receptor (EGFR) ligands, such as epidermal growth factor (EGF) and amphiregulin (AREG)", " EGFR ligands epidermal growth factor (EGF), amphiregulin (AREG) and transforming growth factor alpha (TGFα)", " EGFR and its ligand EGF ", "Among EGFR ligands, heparin-binding EGF-like growt...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23959273", "http://www.ncbi.nlm.nih.gov/pubmed/21514161", "http://www.ncbi.nlm.nih.gov/pubmed/23787814", "http://www.ncbi.nlm.nih.gov/pubmed/23888072", "http://www.ncbi.nlm.nih.gov/pubmed/23821377", "http://www.ncbi.nlm.nih.gov/pubmed/24124521", "http://www.ncbi.nlm.n...	[ { "p": "http://purl.uniprot.org/core/encodedBy", "s": "http://purl.uniprot.org/uniprot/Q9QX70", "o": "http://linkedlifedata.com/resource/#_5139515837300022" }, { "p": "http://www.w3.org/2004/02/skos/core#prefLabel", "s": "http://linkedlifedata.com/resource/#_5139515837300022", "o": "Egfr...	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005154", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007176", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005488", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042058", "htt...
54e25eaaae9738404b000017	yesno	Is the protein Papilin secreted?	[ "Yes, papilin is a secreted protein" ]	[ "yes" ]	[ "Using expression analysis, we identify three genes that are transcriptionally regulated by HLH-2: the protocadherin cdh-3, and two genes encoding secreted extracellular matrix proteins, mig-6/papilin and him-4/hemicentin. ", "We found that mig-6 encodes long (MIG-6L) and short (MIG-6S) isoforms of the extracellu...	[ "http://www.ncbi.nlm.nih.gov/pubmed/3320045", "http://www.ncbi.nlm.nih.gov/pubmed/7515725", "http://www.ncbi.nlm.nih.gov/pubmed/20805556", "http://www.ncbi.nlm.nih.gov/pubmed/19297413", "http://www.ncbi.nlm.nih.gov/pubmed/19724244", "http://www.ncbi.nlm.nih.gov/pubmed/15094122", "http://www.ncbi.nlm.nih...	[]	[]
535d292a9a4572de6f000003	yesno	Are long non coding RNAs spliced?	[ "Long non coding RNAs appear to be spliced through the same pathway as the mRNAs" ]	[ "yes" ]	[ "Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths.", "For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/22955988", "http://www.ncbi.nlm.nih.gov/pubmed/22955974", "http://www.ncbi.nlm.nih.gov/pubmed/24285305", "http://www.ncbi.nlm.nih.gov/pubmed/22707570", "http://www.ncbi.nlm.nih.gov/pubmed/21622663", "http://www.ncbi.nlm.nih.gov/pubmed/24106460" ]	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012326", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062085" ]
55262a9787ecba3764000009	yesno	Is RANKL secreted from the cells?	[ "Receptor activator of nuclear factor κB ligand (RANKL) is a cytokine predominantly secreted by osteoblasts." ]	[ "yes" ]	[ "Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) ", "Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastoge...	[ "http://www.ncbi.nlm.nih.gov/pubmed/22948539", "http://www.ncbi.nlm.nih.gov/pubmed/23698708", "http://www.ncbi.nlm.nih.gov/pubmed/23827649", "http://www.ncbi.nlm.nih.gov/pubmed/22901753", "http://www.ncbi.nlm.nih.gov/pubmed/21618594", "http://www.ncbi.nlm.nih.gov/pubmed/23835909", "http://www.ncbi.nlm.n...	[]	[ "http://www.uniprot.org/uniprot/TNF11_RAT", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015870", "http://www.uniprot.org/uniprot/TNF11_HUMAN" ]
51406e6223fec90375000009	yesno	Does metformin interfere thyroxine absorption?	[ "There are not reported data indicating that metformin interferes with thyroxine absorption" ]	[ "no" ]	[]	[ "http://www.ncbi.nlm.nih.gov/pubmed/23264396", "http://www.ncbi.nlm.nih.gov/pubmed/21633823", "http://www.ncbi.nlm.nih.gov/pubmed/23554450", "http://www.ncbi.nlm.nih.gov/pubmed/23244059", "http://www.ncbi.nlm.nih.gov/pubmed/21041167", "http://www.ncbi.nlm.nih.gov/pubmed/21748540", "http://www.ncbi.nlm.n...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013974", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008687", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000042" ]
553fa78b1d53b76422000007	list	Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer?	[ "miR-200a, miR-100, miR-141, miR-200b, miR-200c, miR-203, miR-510, miR-509-5p, miR-132, miR-26a, let-7b, miR-145, miR-182, miR-152, miR-148a, let-7a, let-7i, miR-21, miR-92 and miR-93 could be used as potential biomarkers for epithelial ovarian cancer." ]	[ "let-7a", "let-7b", "let-7i", "miR-21", "miR-26a", "miR-92", "miR-93", "miR-100", "miR-132", "miR-141", "miR-145", "miR-148a", "miR-152", "miR-182", "miR-200a", "miR-200b", "miR-200c", "miR-203", "miR-509-5p", "miR-510" ]	[ "Finally, five promising differentially miRNAs (miR-200a, miR-100, miR-141, miR-200b, and miR-200c) were reported with the consistent direction in four or more studies. MiR-200a, miR-200b, miR-200c, and miR-141, all of them belong to miR-200 family, were reported with consistently up-regulated in at least 4 studies...	[ "http://www.ncbi.nlm.nih.gov/pubmed/21345725", "http://www.ncbi.nlm.nih.gov/pubmed/22246341", "http://www.ncbi.nlm.nih.gov/pubmed/23888941", "http://www.ncbi.nlm.nih.gov/pubmed/23836287", "http://www.ncbi.nlm.nih.gov/pubmed/23542579", "http://www.ncbi.nlm.nih.gov/pubmed/23978303", "http://www.ncbi.nlm.n...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015415", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010051", "http://www.disease-ontology.org/a...
5149199dd24251bc05000040	list	Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis?	[ "Pyridostigmine and neostygmine are acetylcholinesterase inhibitors that are used as first-line therapy for symptomatic treatment of myasthenia gravis. Pyridostigmine is the most widely used acetylcholinesterase inhibitor. Extended release pyridotsygmine and novel acetylcholinesterase inhibitors inhibitors with ora...	[ "neostigmine", "pyridostigmine" ]	[ "Pyridostigmine is the most widely used acetylcholinesterase inhibitor.", "For more than 50 years the acetylcholinesterase inhibitor pyridostigmine bromide has been the drug of choice in the symptomatic therapy for myasthenia gravis. ", "The switch to SR-Pyr ameliorated the total quantified myasthenia gravis (Q...	[ "http://www.ncbi.nlm.nih.gov/pubmed/21815707", "http://www.ncbi.nlm.nih.gov/pubmed/21845054", "http://www.ncbi.nlm.nih.gov/pubmed/21328290", "http://www.ncbi.nlm.nih.gov/pubmed/20663605", "http://www.ncbi.nlm.nih.gov/pubmed/21133188", "http://www.ncbi.nlm.nih.gov/pubmed/15610702" ]	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000110", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009157", "http://www.disease-ontology.org/api/metadata/DOID:437", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exa...
52bf1db603868f1b06000011	yesno	Has Denosumab (Prolia) been approved by FDA?	[ "Yes, Denosumab was approved by the FDA in 2010." ]	[ "yes" ]	[ "Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors.", " The authors present the imaging findings and technical report of an attempted percutaneous vertebroplasty in the only patient found to be activ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/24126422", "http://www.ncbi.nlm.nih.gov/pubmed/22826702", "http://www.ncbi.nlm.nih.gov/pubmed/23759273", "http://www.ncbi.nlm.nih.gov/pubmed/21785279", "http://www.ncbi.nlm.nih.gov/pubmed/21113693", "http://www.ncbi.nlm.nih.gov/pubmed/21129866", "http://www.ncbi.nlm.n...	[ { "p": "http://www.w3.org/2004/02/skos/core#note", "s": "http://linkedlifedata.com/resource/umls/label/A18043383", "o": "FDA Structured Product Labels" }, { "p": "http://www.w3.org/2008/05/skos-xl#altLabel", "s": "http://linkedlifedata.com/resource/umls/id/C1690432", "o": "http://linkedl...	[ "http://www.biosemantics.org/jochem#4268082" ]
5709e4b2cf1c32585100001c	list	List the human genes encoding for the dishevelled proteins?	[ "DVL-1\nDVL-2\nDVL-3" ]	[ "DVL-1", "DVL-2", "DVL-3" ]	[ "Dishevelled (Dvl/Dsh) is a multi-module protein and a key regulator of both the canonical Wnt and the PCP pathway. In mouse, all Dvl1(-/-) ; Dvl2(-/-) double mutants display craniorachischisis, a severe form of open NTDs. ", " In this study, we explore the cause of HSCR by studying the expression of DVL-1 and DV...	[ "http://www.ncbi.nlm.nih.gov/pubmed/12883684", "http://www.ncbi.nlm.nih.gov/pubmed/24040443", "http://www.ncbi.nlm.nih.gov/pubmed/19618470", "http://www.ncbi.nlm.nih.gov/pubmed/8817329", "http://www.ncbi.nlm.nih.gov/pubmed/8856345", "http://www.ncbi.nlm.nih.gov/pubmed/23836490", "http://www.ncbi.nlm.nih...	[]	[]
56bc751eac7ad10019000013	factoid	Name synonym of Acrokeratosis paraneoplastica.	[ "Acrokeratosis paraneoplastic (Bazex syndrome) is a rare, but distinctive paraneoplastic dermatosis characterized by erythematosquamous lesions located at the acral sites and is most commonly associated with carcinomas of the upper aerodigestive tract." ]	[ "Bazex syndrome" ]	[ "Acrokeratosis paraneoplastica of Bazex is a rare but important paraneoplastic dermatosis, usually manifesting as psoriasiform rashes over the acral sites.", "[Paraneoplastic palmoplantar hyperkeratosis. Minor form of acrokeratosis neoplastica Bazex?].", "Acrokeratosis paraneoplastica Bazex is a rare, obligate ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/3819049", "http://www.ncbi.nlm.nih.gov/pubmed/18775590", "http://www.ncbi.nlm.nih.gov/pubmed/22146896", "http://www.ncbi.nlm.nih.gov/pubmed/6225397", "http://www.ncbi.nlm.nih.gov/pubmed/18672707", "http://www.ncbi.nlm.nih.gov/pubmed/7796616", "http://www.ncbi.nlm.nih....	[]	[]
54d4e03a3706e89528000001	list	Which are the classes of anti-arrhythmic drugs according to Vaughan-Williams classification?	[ "Antiarrhythmic drugs can be divided into four Vaughan Williams classes (I-IV). Class I antiarrhythmic agents have as a common action, blockade of the sodium channels. Class II agents are antisympathetic drugs, particularly the beta-adrenoceptor blockers. Class-III antiarrhythmics have as a common action the potass...	[ "Class I: sodium channel blockers", "ClassII: beta blockers", "Class III: potassium channel blockers", "Class IV: calcium channel blockers" ]	[ "Class II agents are antisympathetic drugs, particularly the beta-adrenoceptor blockers", "Class III antiarrhythmic agents include sotalol and amiodarone.", "Class IV antiarrhythmic drugs are the calcium channel blockers verapamil and diltiazem. ", "Other agents which do not fall neatly into the Vaughan Willi...	[ "http://www.ncbi.nlm.nih.gov/pubmed/9803978", "http://www.ncbi.nlm.nih.gov/pubmed/11564050", "http://www.ncbi.nlm.nih.gov/pubmed/1290288", "http://www.ncbi.nlm.nih.gov/pubmed/7875632", "http://www.ncbi.nlm.nih.gov/pubmed/10810787" ]	[]	[]
55072c803b8a5dc045000001	list	Which are the different isoforms of the mammalian Notch receptor?	[ "Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man: Notch-1, Notch-2, Notch-3 and Notch-4." ]	[ "Notch-1", "Notch-2", "Notch-3", "Notch-4" ]	[ "Here, we investigate protein interactions between NOTCH3 and other vascular Notch isoforms and characterize the effects of elevated NOTCH3 on smooth muscle gene regulation. We demonstrate that NOTCH3 forms heterodimers with NOTCH1, NOTCH3, and NOTCH4.", "We conclude that CADASIL mutants of NOTCH3 complex with NO...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23028706", "http://www.ncbi.nlm.nih.gov/pubmed/21639801", "http://www.ncbi.nlm.nih.gov/pubmed/11532344", "http://www.ncbi.nlm.nih.gov/pubmed/22842086", "http://www.ncbi.nlm.nih.gov/pubmed/21356309", "http://www.ncbi.nlm.nih.gov/pubmed/11732008", "http://www.ncbi.nlm.n...	[]	[]
53061af558348c0f52000002	list	Which are the major characteristics of cellular senescence?	[ "The defining characteristics of cellular senescence are altered morphology, arrested cell-cycle progression, development of aberrant gene expression with proinflammatory behavior, and telomere shortening." ]	[ "altered morphology", "arrested cell-cycle progression", "development of aberrant gene expression with proinflammatory behavior", "telomere shortening" ]	[ "Cellular senescence is recognized as a critical cellular response to prolonged rounds of replication and environmental stresses. Its defining characteristics are arrested cell-cycle progression and the development of aberrant gene expression with proinflammatory behavior.", "telomeres are the central timing mech...	[ "http://www.ncbi.nlm.nih.gov/pubmed/9624027", "http://www.ncbi.nlm.nih.gov/pubmed/18976161", "http://www.ncbi.nlm.nih.gov/pubmed/8824885" ]	[]	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090398", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016922", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000772", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:...
56c1f01def6e394741000045	factoid	Orteronel was developed for treatment of which cancer?	[ "Orteronel was developed for treatment of castration-resistant prostate cancer." ]	[ "castration-resistant prostate cancer" ]	[ "Pooled-analysis was also performed, to assess the effectiveness of agents targeting the androgen axis via identical mechanisms of action (abiraterone acetate, orteronel).", "The experimental interventions tested in these studies were enzalutamide, ipilimumab, abiraterone acetate, orteronel and cabazitaxel. ", ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/24799061", "http://www.ncbi.nlm.nih.gov/pubmed/24418642", "http://www.ncbi.nlm.nih.gov/pubmed/25537627", "http://www.ncbi.nlm.nih.gov/pubmed/25701170", "http://www.ncbi.nlm.nih.gov/pubmed/25624429", "http://www.ncbi.nlm.nih.gov/pubmed/25264242", "http://www.ncbi.nlm.n...	[]	[ "http://www.disease-ontology.org/api/metadata/DOID:162" ]
5313b049e3eabad021000013	yesno	Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer?	[ "Although is still controversial, Trastuzumab (Herceptin) can be of potential use in the treatment of prostate cancer overexpressing HER2, either alone or in combination with other drugs." ]	[ "yes" ]	[ "Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial.", "Our data demonstrate that Re-188-labeled Herceptin effectively inhibited the growth of DU145 cells compared to the Herceptin- and Re-188-treated cohorts. Thi...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23294030", "http://www.ncbi.nlm.nih.gov/pubmed/10473102", "http://www.ncbi.nlm.nih.gov/pubmed/11786427", "http://www.ncbi.nlm.nih.gov/pubmed/17210707", "http://www.ncbi.nlm.nih.gov/pubmed/21364123", "http://www.ncbi.nlm.nih.gov/pubmed/12173324", "http://www.ncbi.nlm.n...	[]	[ "http://www.biosemantics.org/jochem#4002084", "http://www.disease-ontology.org/api/metadata/DOID:10283" ]
54d643023706e89528000007	factoid	Which is the protein that is encoded by the gene GLT8D1?	[ "The GLT8D1 gene codes for the protein named glycosyltransferase 8 domain containing 1" ]	[ "glycosyltransferase 8 domain containing 1" ]	[]	[ "http://www.ncbi.nlm.nih.gov/pubmed/24114764", "http://www.ncbi.nlm.nih.gov/pubmed/24373612" ]	[ { "p": "http://purl.uniprot.org/core/encodedBy", "s": "http://purl.uniprot.org/uniprot/C9JY96", "o": "http://linkedlifedata.com/resource/#_43394A593936009" }, { "p": "http://www.w3.org/2004/02/skos/core#prefLabel", "s": "http://linkedlifedata.com/resource/#_43394A593936009", "o": "GLT8D1...	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757", "http://www.uniprot.org/uniprot/GL8D1_DANRE", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016695", "http://www.uniprot.org/uniprot/GL8D1_BOVIN" ]
53137541e3eabad021000010	list	Which are the Yamanaka factors?	[ "The Yamanaka factors are the OCT4, SOX2, MYC, and KLF4 transcription factors" ]	[ "OCT4", "Oct3/4", "Pou5f1", "SOX2", "MYC", "c-MYC", "KLF4" ]	[ "Yamanaka factors (OCT4, SOX2, MYC, and KLF4", "Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc)", "Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) ", "Yamanaka factors (c-myc, KLF4, Oct3/4 and SOX2)", "Yamanaka factors (i.e., Oct4, Sox2, Klf4, and c-Myc) ", "Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc)"...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23658991", "http://www.ncbi.nlm.nih.gov/pubmed/21839145", "http://www.ncbi.nlm.nih.gov/pubmed/23612755", "http://www.ncbi.nlm.nih.gov/pubmed/21761058", "http://www.ncbi.nlm.nih.gov/pubmed/23939864", "http://www.ncbi.nlm.nih.gov/pubmed/24150221", "http://www.ncbi.nlm.n...	[]	[]
515aa0abd24251bc050000a8	summary	What is the aim of the Human Chromosome-centric Proteome Project (C-HPP)?	[ "The chromosome-centric human proteome project aims to systematically map all human proteins, chromosome by chromosome, in a gene-centric manner through dedicated efforts from national and international teams", "The Chromosome-Centric Human Proteome Project (C-HPP) is an international effort for creating an annot...	[]	[ "The Chromosome-Centric Human Proteome Project (C-HPP) is an international effort for creating an annotated proteomic catalog for each chromosome", "The chromosome-centric human proteome project aims to systematically map all human proteins, chromosome by chromosome, in a gene-centric manner through dedicated eff...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23312004", "http://www.ncbi.nlm.nih.gov/pubmed/23253012", "http://www.ncbi.nlm.nih.gov/pubmed/23252913", "http://www.ncbi.nlm.nih.gov/pubmed/22966780", "http://www.ncbi.nlm.nih.gov/pubmed/23249167", "http://www.ncbi.nlm.nih.gov/pubmed/23259496", "http://www.ncbi.nlm.n...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006801", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020543", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002875", "http://www.nlm.nih.gov/cgi/mesh/2...
56af9f130a360a5e45000015	factoid	Where is the protein Pannexin1 located?	[ "The protein Pannexin1 is localized to the plasma membranes." ]	[ "plasma membrane" ]	[ "zfPanx1 was identified on the surface of horizontal cell dendrites invaginating deeply into the cone pedicle near the glutamate release sites of the cones, providing in vivo evidence for hemichannel formation at that location.", "pannexin1, a vertebrate homolog of invertebrate gap junction proteins.", "The spe...	[ "http://www.ncbi.nlm.nih.gov/pubmed/24642372", "http://www.ncbi.nlm.nih.gov/pubmed/25056878", "http://www.ncbi.nlm.nih.gov/pubmed/24694658", "http://www.ncbi.nlm.nih.gov/pubmed/25698922", "http://www.ncbi.nlm.nih.gov/pubmed/17064878", "http://www.ncbi.nlm.nih.gov/pubmed/24782784", "http://www.ncbi.nlm.n...	[ { "p": "http://www.w3.org/2004/02/skos/core#notation", "s": "http://linkedlifedata.com/resource/umls/label/A17397470", "o": "C544702" }, { "p": "http://linkedlifedata.com/resource/umls/altMetaMap", "s": "http://linkedlifedata.com/resource/umls/id/C2743999", "o": "http://linkedlifedata.co...	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051179" ]
5718bbb37de986d80d00000b	list	Which currently known mitochondrial diseases have been attributed to POLG mutations?	[ "Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease that include: 1) childhood Myocerebrohepatopathy Spectrum disorders (MCHS), ...	[ "childhood Myocerebrohepatopathy Spectrum disorders (MCHS)", "Alpers syndrome", "Ataxia Neuropathy Spectrum (ANS) disorders", "Myoclonus Epilepsy Myopathy Sensory Ataxia (MEMSA)", "autosomal recessive Progressive External Ophthalmoplegia (arPEO)", "autosomal dominant Progressive External Ophthalmoplegia (...	[ "Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease that include: 1) childhood Myocerebrohepatopathy Spectrum disorders (MCHS), ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/18546365", "http://www.ncbi.nlm.nih.gov/pubmed/12825077", "http://www.ncbi.nlm.nih.gov/pubmed/22647225", "http://www.ncbi.nlm.nih.gov/pubmed/15351195", "http://www.ncbi.nlm.nih.gov/pubmed/20927567" ]	[]	[]
532f062ad6d3ac6a34000027	summary	What is the effect of ivabradine in heart failure after myocardial infarction?	[ "Ιvabradine decreases heart rate and reduces myocardial oxygen demand, increases diastolic perfusion time and improves energetics in ischemic myocardium. Ivabradine protects the myocardium during ischemia, improves left ventricular function in heart failure and reduces remodeling following myocardial infarction. It...	[]	[ "Ivabradine may be important for the improvement of clinical outcomes in patients with LV systolic dysfunction and heart rate ≥ 70 b.p.m., whatever the primary clinical presentation (CAD or HF) or clinical status (NYHA class).", "Treatment with ivabradine was associated with a 13% relative risk reduction for the ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/21838751", "http://www.ncbi.nlm.nih.gov/pubmed/19074674", "http://www.ncbi.nlm.nih.gov/pubmed/18310678", "http://www.ncbi.nlm.nih.gov/pubmed/23067195", "http://www.ncbi.nlm.nih.gov/pubmed/18757088", "http://www.ncbi.nlm.nih.gov/pubmed/20000882", "http://www.ncbi.nlm.n...	[]	[ "http://www.biosemantics.org/jochem#4266225", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009203", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054143" ]
52bf1b0a03868f1b06000009	factoid	What is the mode of inheritance of Wilson's disease?	[ "Wilson's disease (WD) is an autosomal recessive disorder." ]	[ "autosomal recessive" ]	[ "The disease has an autosomal recessive mode of inheritance, and is characterized by excessive copper deposition, predominantly in the liver and brain.", " The inheritance is autosomal recessive. ", "Wilson's disease (WD), or hepatolenticular degeneration, is an autosomal recessive inheritance disorder of coppe...	[ "http://www.ncbi.nlm.nih.gov/pubmed/838566", "http://www.ncbi.nlm.nih.gov/pubmed/12152840", "http://www.ncbi.nlm.nih.gov/pubmed/20662462", "http://www.ncbi.nlm.nih.gov/pubmed/16932613", "http://www.ncbi.nlm.nih.gov/pubmed/1248830", "http://www.ncbi.nlm.nih.gov/pubmed/22610954", "http://www.ncbi.nlm.nih....	[ { "p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/diseaseSubtypeOf", "s": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/4181", "o": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1198" }, { "p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/d...	[ "http://www.disease-ontology.org/api/metadata/DOID:4", "http://www.disease-ontology.org/api/metadata/DOID:893", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006527", "h...
517395b98ed59a060a00001a	yesno	Are transcription and splicing connected?	[ "Yes. There is strong evidence that splicing and transcription are intimately coupled in metazoans, with genome wide surveys show that most splicing occurs during transcription. Chromatin structure, RNA polymerase dynamics, and recruitment of splicing factors through the transcriptional machinery are factors that ...	[ "yes" ]	[ ", as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of splicing factor binding to their pre-mRNA target sites but also on transcription-associated features such as protein recruitment to the transcribing machinery and elongation kinetics....	[ "http://www.ncbi.nlm.nih.gov/pubmed/20808788", "http://www.ncbi.nlm.nih.gov/pubmed/23074139", "http://www.ncbi.nlm.nih.gov/pubmed/23097425", "http://www.ncbi.nlm.nih.gov/pubmed/17189193", "http://www.ncbi.nlm.nih.gov/pubmed/21964334", "http://www.ncbi.nlm.nih.gov/pubmed/16921380", "http://www.ncbi.nlm.n...	[]	[]
52bf19c503868f1b06000001	factoid	What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?	[ "Facioscapulohumeral muscular dystrophy has an autosomal dominant inheritance pattern." ]	[ "autosomal dominant" ]	[ "autosomal dominant FSHD1", "Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disease, characterized by an autosomal dominant mode of inheritance, facial involvement, and selectivity and asymmetry of muscle involvement.", "Facioscapulohumeral dystrophy (FSHD) is an autosomal-dominant disorder ch...	[ "http://www.ncbi.nlm.nih.gov/pubmed/10487912", "http://www.ncbi.nlm.nih.gov/pubmed/15307599", "http://www.ncbi.nlm.nih.gov/pubmed/10969520", "http://www.ncbi.nlm.nih.gov/pubmed/19248726", "http://www.ncbi.nlm.nih.gov/pubmed/10864616", "http://www.ncbi.nlm.nih.gov/pubmed/7739631", "http://www.ncbi.nlm.ni...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040582", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014918" ]
54db1d580f63c58e6e000005	yesno	Is Alu hypomethylation associated with breast cancer?	[ "Yes, Alu elements were found to be hypomethylated in breast cancer, especially in the HER2-enriched subtype. Furthermore, Alu hypomethylation was identified as a late event during breast cancer progression, and in invasive breast cancer, tended to be associated with negative estrogen receptor status and poor disea...	[ "yes" ]	[ "Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer", "In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status", "In survival analyses, low Alu methylation status tended to be associated with poor disease-free survival of the patients.", "Alu hy...	[ "http://www.ncbi.nlm.nih.gov/pubmed/20682973", "http://www.ncbi.nlm.nih.gov/pubmed/24971511" ]	[]	[ "http://www.disease-ontology.org/api/metadata/DOID:1612" ]
54f9d3eedd3fc62544000004	list	Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex?	[ "Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex with the ryanodine receptor (Ca(2+) release channel), triadin, and calsequestrin. ", "Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor...	[ "Ryanodine receptor", "RyR", "Calsequestrin", "CASQ", "CSQ", "Triadin", "TrD", "TRN", "Junctin", "JCN", "JnC", "JUN" ]	[ "Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplasmic reticulum (SR).", "The decrease of CASQ2 is associated with a reduction in the lev...	[ "http://www.ncbi.nlm.nih.gov/pubmed/12909320", "http://www.ncbi.nlm.nih.gov/pubmed/11069905", "http://www.ncbi.nlm.nih.gov/pubmed/15205169", "http://www.ncbi.nlm.nih.gov/pubmed/22298808", "http://www.ncbi.nlm.nih.gov/pubmed/22025663", "http://www.ncbi.nlm.nih.gov/pubmed/18620751", "http://www.ncbi.nlm.n...	[]	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020836", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019837" ]
5505edac8e1671127b000005	factoid	What kind of chromatography is HILIC?	[ "Hydrophilic Interaction Chromatography (HILIC)" ]	[ "Hydrophilic Interaction Chromatography" ]	[ "hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC LC-MS/MS) method", "Hydrophilic-interaction liquid chromatography (HILIC) is a widely used technique for small polar molecule analysis ", "hydrophilic-interaction LC (HILIC)", "A hydrophilic interaction liquid chromatography-tandem...	[ "http://www.ncbi.nlm.nih.gov/pubmed/21737084", "http://www.ncbi.nlm.nih.gov/pubmed/23217321", "http://www.ncbi.nlm.nih.gov/pubmed/22946920", "http://www.ncbi.nlm.nih.gov/pubmed/23073287", "http://www.ncbi.nlm.nih.gov/pubmed/21238772", "http://www.ncbi.nlm.nih.gov/pubmed/21316059" ]	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002845" ]
5160193d298dcd4e51000039	summary	What is the effect of TRH on myocardial contractility?	[ "TRH improves myocardial contractility" ]	[]	[ "Acute intravenous administration of TRH to rats with ischemic cardiomyopathy caused a significant increase in heart rate, mean arterial pressure, cardiac output, stroke volume, and cardiac contractility", "TRH can enhance cardiomyocyte contractility in vivo.", "TRH in the range of 0.1-10 mumol/l was found to e...	[ "http://www.ncbi.nlm.nih.gov/pubmed/9225129", "http://www.ncbi.nlm.nih.gov/pubmed/1979356", "http://www.ncbi.nlm.nih.gov/pubmed/9088928", "http://www.ncbi.nlm.nih.gov/pubmed/15096458", "http://www.ncbi.nlm.nih.gov/pubmed/2848686", "http://www.ncbi.nlm.nih.gov/pubmed/1611701" ]	[]	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0008437", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003285", "http://www.uniprot.org/uniprot/TRFR_MOUSE", "http://www.uniprot.org/uniprot/TRFR_CHICK", "http://www.disease-ontology.org/api/metadata/DOID:11...
51593dc8d24251bc05000099	yesno	Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available?	[ "Yes, the complete genome sequence of Arthrobacter (two strains) is deposited in GenBank." ]	[ "yes" ]	[]	[ "http://www.ncbi.nlm.nih.gov/pubmed/21677849", "http://www.ncbi.nlm.nih.gov/pubmed/23039946" ]	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001173", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016678" ]
56e2cec751531f7e33000015	factoid	What is the structural fold of bromodomain proteins?	[ "The structure fold of the bromodomains is an all-alpha-helical fold, which includes a left-handed four-helix bundle topology, with two short additional helices in a long connecting loop." ]	[ "All-alpha-helical fold" ]	[ "These new studies also support the notion that functional diversity of a conserved bromodomain structural fold is achieved by evolutionary changes of structurally flexible amino-acid sequences in the ligand binding site such as the ZA and BC loops.", "Although the overall fold resembles the bromodomains from oth...	[ "http://www.ncbi.nlm.nih.gov/pubmed/17498659", "http://www.ncbi.nlm.nih.gov/pubmed/10365964", "http://www.ncbi.nlm.nih.gov/pubmed/17694091", "http://www.ncbi.nlm.nih.gov/pubmed/10827952", "http://www.ncbi.nlm.nih.gov/pubmed/17148447", "http://www.ncbi.nlm.nih.gov/pubmed/17582821", "http://www.ncbi.nlm.n...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506" ]
515deafd298dcd4e51000025	list	List the endoscopic diagnoses that have been reported in children with autism	[ "Endoscopic examinations in autistic children have been reported to show : I or II reflux esophagitis, Achalasia, chronic gastritis and chronic duodenitis, mild acute and chronic inflammation of the small bowel and colorectum and Ileo-colonic lymphoid nodular hyperplasia (LNH). \nThe number of Paneth's cells in ...	[ "Reflux esophagitis", "Achalasia", "chronic gastritis", "chronic duodenitis", "inflammation of the small bowel and colorectum", "Ileo-colonic lymphoid nodular hyperplasia (LNH)" ]	[ "Autism and esophageal achalasia in childhood: a possible correlation?", "In the last case, a 15-year-old male underwent barium swallow and endoscopy that confirmed achalasia.", "Intestinal mucosal pathology, characterized by ileo-colonic lymphoid nodular hyperplasia (LNH) and mild acute and chronic inflammatio...	[ "http://www.ncbi.nlm.nih.gov/pubmed/11007230", "http://www.ncbi.nlm.nih.gov/pubmed/22607127", "http://www.ncbi.nlm.nih.gov/pubmed/16003132", "http://www.ncbi.nlm.nih.gov/pubmed/9585670", "http://www.ncbi.nlm.nih.gov/pubmed/10547242", "http://www.ncbi.nlm.nih.gov/pubmed/12907332" ]	[]	[ "http://www.disease-ontology.org/api/metadata/DOID:12849", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001321", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016099", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+E...
532624ae600967d132000005	summary	What are the outcomes of Renal sympathetic denervation?	[ "Significant decreases and progressively higher reductions of systolic and diastolic blood pressure were observed after RSD. The complication rate was minimal.\nRenal sympathetic denervation also reduces heart rate, which is a surrogate marker of cardiovascular risk." ]	[]	[ "Significant decreases and progressively higher reductions of systolic and diastolic blood pressure were observed after RSD. The complication rate was minimal. ", "In conclusion, the RSD presents itself as an effective and safe approach to resistant hypertension.", "Renal sympathetic denervation delivers not on...	[ "http://www.ncbi.nlm.nih.gov/pubmed/21247927", "http://www.ncbi.nlm.nih.gov/pubmed/22573363", "http://www.ncbi.nlm.nih.gov/pubmed/23176687", "http://www.ncbi.nlm.nih.gov/pubmed/23541665", "http://www.ncbi.nlm.nih.gov/pubmed/23774592", "http://www.ncbi.nlm.nih.gov/pubmed/24029963", "http://www.ncbi.nlm.n...	[ { "p": "http://www.w3.org/2004/02/skos/core#notation", "s": "http://linkedlifedata.com/resource/umls/label/A0121834", "o": "U004557" }, { "p": "http://linkedlifedata.com/resource/umls/prefMetaMap", "s": "http://linkedlifedata.com/resource/umls/id/C0039038", "o": "http://linkedlifedata.co...	[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013563", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013562", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003714", "http://www.nlm.nih.gov/cgi/mesh/2...
5518e7da622b194345000004	factoid	Which MAP kinase phosphorylates the transcription factor c-jun?	[ "c-Jun is phosphorylated by c-Jun NH2-terminal kinase (JNK).", "An in vitro kinase assay revealed that c-Jun phosphorylation is primarily mediated via activated c-Jun N-terminal protein kinase (JNK)." ]	[ "c-Jun NH2-terminal kinase", "JNK" ]	[ " c-Jun NH2-terminal kinase (JNK)", " c-jun N-terminal kinase (JNK) of mitogen-activated protein kinase (MAPK) family ", "-Jun N-terminal kinase (JNK)", "activated c-Jun N-terminal kinase (JNK)", "-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathways", " c-Jun N-terminal ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/24113186", "http://www.ncbi.nlm.nih.gov/pubmed/24300195", "http://www.ncbi.nlm.nih.gov/pubmed/24272171", "http://www.ncbi.nlm.nih.gov/pubmed/24291243", "http://www.ncbi.nlm.nih.gov/pubmed/24252081", "http://www.ncbi.nlm.nih.gov/pubmed/15228586", "http://www.ncbi.nlm.n...	[]	[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007257", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007258", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016755" ]
530a5117970c65fa6b000007	factoid	What is the meaning of the acronym "TAILS" used in protein N-terminomics?	[ "TAILS stands for \"Terminal Amine Isotopic Labeling of Substrates\"" ]	[ "TAILS: Terminal Amine Isotopic Labeling of Substrates" ]	[ ". It is important to identify what proteins are substrates of proteases and where their cleavage sites are so as to reveal the molecular mechanisms and specificity of signaling. ", "It is important to identify what proteins are substrates of proteases and where their cleavage sites are so as to reveal the molecu...	[ "http://www.ncbi.nlm.nih.gov/pubmed/22577022", "http://www.ncbi.nlm.nih.gov/pubmed/23667905", "http://www.ncbi.nlm.nih.gov/pubmed/21604129", "http://www.ncbi.nlm.nih.gov/pubmed/20305284", "http://www.ncbi.nlm.nih.gov/pubmed/22367194" ]	[]	[ "http://www.uniprot.org/uniprot/TERM_DROME", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506" ]
56bf365eef6e39474100000e	yesno	Do mutations of AKT1 occur in meningiomas?	[ "Yes, AKT1 mutation occurs in meningiomas." ]	[ "yes" ]	[ "The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas.", "A mutation in PIK3CA or AKT1 was found in around 9 % of the cases.", "AKT1E17K mutations cluster with meni...	[ "http://www.ncbi.nlm.nih.gov/pubmed/25146167", "http://www.ncbi.nlm.nih.gov/pubmed/23475883", "http://www.ncbi.nlm.nih.gov/pubmed/23348505", "http://www.ncbi.nlm.nih.gov/pubmed/23334667", "http://www.ncbi.nlm.nih.gov/pubmed/24096618", "http://www.ncbi.nlm.nih.gov/pubmed/25857641" ]	[]	[ "http://www.biosemantics.org/jochem#4264173", "http://www.disease-ontology.org/api/metadata/DOID:3565", "http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009154", "http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008579" ]
52bf202003868f1b06000018	list	What are the main indications of lacosamide?	[ "Lacosamide is an anti-epileptic drug, licensed for refractory partial-onset seizures. In addition to this, it has demonstrated analgesic activity in various animal models. Apart from this, LCM has demonstrated potent effects in animal models for a variety of CNS disorders like schizophrenia and stress induced anxi...	[ "epilepsy", "refractory epilepsy", "refractory partial-onset seizures", "analgesic", "CNS disorders" ]	[ "The current article presents a concise review of network theory and its application to the characterization of AED use in children with refractory epilepsy.", "Furthermore, first generation AEDs were often discontinued, while lacosamide and topiramate were most likely to be initiated. ", "Overall, there is com...	[ "http://www.ncbi.nlm.nih.gov/pubmed/23288091", "http://www.ncbi.nlm.nih.gov/pubmed/17461888", "http://www.ncbi.nlm.nih.gov/pubmed/23648276", "http://www.ncbi.nlm.nih.gov/pubmed/20677583", "http://www.ncbi.nlm.nih.gov/pubmed/21861814", "http://www.ncbi.nlm.nih.gov/pubmed/21301338", "http://www.ncbi.nlm.n...	[ { "p": "http://www.w3.org/2004/02/skos/core#notation", "s": "http://linkedlifedata.com/resource/umls/label/A16033679", "o": "563KS2PQY5" }, { "p": "http://www.w3.org/2008/05/skos-xl#altLabel", "s": "http://linkedlifedata.com/resource/umls/id/C0893761", "o": "http://linkedlifedata.com/res...	[ "http://www.biosemantics.org/jochem#4267957" ]
552fac4fbc4f83e828000006	factoid	Which fusion protein is involved in the development of Ewing sarcoma?	[ "Ewing sarcoma is the second most common bone malignancy in children and young adults. In almost 95% of the cases, it is driven by oncogenic fusion protein EWS/FLI1, which acts as an aberrant transcription factor, that upregulates or downregulates target genes, leading to cellular transformation." ]	[ "EWS/FLI1" ]	[ "Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate and downregulate target genes, leading to cellular transformation", "EWS/FLI-1 oncoprotein subtypes impose diffe...	[ "http://www.ncbi.nlm.nih.gov/pubmed/25432018", "http://www.ncbi.nlm.nih.gov/pubmed/21979944", "http://www.ncbi.nlm.nih.gov/pubmed/16206264", "http://www.ncbi.nlm.nih.gov/pubmed/18256529", "http://www.ncbi.nlm.nih.gov/pubmed/25162919", "http://www.ncbi.nlm.nih.gov/pubmed/19718047", "http://www.ncbi.nlm.n...	[]	[ "http://www.disease-ontology.org/api/metadata/DOID:3368", "http://www.disease-ontology.org/api/metadata/DOID:4980", "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012512" ]
56be0da3ef6e394741000007	list	List Hemolytic Uremic Syndrome Triad.	[ "Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by the triad of anaemia, thrombocytopenia, renal failure." ]	[ "anaemia", "thrombocytopenia", "renal failure" ]	[ "Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by the triad of thrombotic microangiopathy, thrombocytopenia, and acute kidney injury.", "Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute r...	[ "http://www.ncbi.nlm.nih.gov/pubmed/25011592", "http://www.ncbi.nlm.nih.gov/pubmed/24161037", "http://www.ncbi.nlm.nih.gov/pubmed/25765799", "http://www.ncbi.nlm.nih.gov/pubmed/8589282", "http://www.ncbi.nlm.nih.gov/pubmed/16387683", "http://www.ncbi.nlm.nih.gov/pubmed/20209841", "http://www.ncbi.nlm.ni...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006463", "http://www.disease-ontology.org/api/metadata/DOID:12554" ]
5158644cd24251bc0500008e	yesno	Does physical activity influence gut hormones?	[ "Yes." ]	[ "yes" ]	[ "Increases in blood PYY(3-36) levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in GLP-1 levels were similar between two different exercise sessions.", "A decrease in serum leptin levels (-48.4%, p < 0.001) was observed after intervention without changes ...	[ "http://www.ncbi.nlm.nih.gov/pubmed/2888163", "http://www.ncbi.nlm.nih.gov/pubmed/23402716", "http://www.ncbi.nlm.nih.gov/pubmed/18987287", "http://www.ncbi.nlm.nih.gov/pubmed/11321513", "http://www.ncbi.nlm.nih.gov/pubmed/21554896", "http://www.ncbi.nlm.nih.gov/pubmed/22619704", "http://www.ncbi.nlm.ni...	[]	[ "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015444" ]

End of preview. Expand in Data Studio

Mutilingual BioASQ-6B

We translate the BioASQ-6B English Question Answering dataset to generate parallel French, Italian and Spanish versions using the NLLB200 3B parameter model. For more info read the original task description: [http://bioasq.org/participate/challenges_year_6](http://bioasq.org/participate/challenges_year_6)

We translate the body, snippets, ideal_answer and exact_answer fields. We have validated the quality of the ideal_answer field, however, the exact_answer field can contain translation artifacts, as NLLB200 often produces low-quality translations of single-word sentences.

📖 Paper: Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain. In LREC-COLING 2024
🌐 Project Website: https://univ-cotedazur.eu/antidote
Original Dataset: http://bioasq.org/participate/challenges_year_6
Funding: CHIST-ERA XAI 2019 call. Antidote (PCI2020-120717-2) funded by MCIN/AEI /10.13039/501100011033 and by European Union NextGenerationEU/PRTR

Citation

@proceedings{garcíaferrero2024medical,
      title={Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain}, 
      author={Iker García-Ferrero and Rodrigo Agerri and Aitziber Atutxa Salazar and Elena Cabrio and Iker de la Iglesia and Alberto Lavelli and Bernardo Magnini and Benjamin Molinet and Johana Ramirez-Romero and German Rigau and Jose Maria Villa-Gonzalez and Serena Villata and Andrea Zaninello},
      year={2024},
      booktitle={Proceedings of LREC-COLING}
}

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Data and models generated within the Antidote Project (https://univ-cotedazur.eu/antidote) • 20 items • Updated about 23 hours ago • 6

Paper for HiTZ/Multilingual-BioASQ-6B

Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain

Paper • 2404.07613 • Published Apr 11, 2024