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- At a glance
- What makes this dataset useful
- Calibration anchors (industry-grade)
- Files in this sample
- Schema (107 columns in primary cohort across 6 modules)
- Primary: Demographics (16 cols)
- Primary: Staging (17 cols)
- Primary: Molecular (24 cols)
- Primary: Surgery (22 cols)
- Primary: Treatment (17 cols)
- Primary: Outcomes (7 cols)
- CA 19-9 Longitudinal Panel (3 cols × ~4,400 rows)
- Surgical Subset (21 cols × ~100 rows)
- Molecular Panel (25 cols × 500 rows)
- Treatment History (8 cols × ~860 rows)
- Primary: Demographics (16 cols)
- Use cases
- Loading examples
- Honest limitations & generator quirks
- What you get in the full commercial product
- Citation
- Contact
HC-ONC-005 — Pancreatic Cancer (PDAC) Synthetic Cohort
Sample dataset (500-patient primary cohort + ~4,400-row CA 19-9 longitudinal panel + 100-row surgical subset + 500-row molecular panel + ~860-row treatment history) from the XpertSystems.ai Synthetic Data Factory — Oncology vertical, SKU 5
A fully synthetic pancreatic ductal adenocarcinoma (PDAC) cohort spanning
the complete clinical pathway: AJCC 8th Edition staging with NCCN
resectability classification (Resectable / Borderline_Resectable /
Locally_Advanced / Metastatic), comprehensive molecular profiling (KRAS
with 7 variants — G12D / G12V / G12R / G12C / G12A / G12S / Q61H — plus
WT; TP53, SMAD4, CDKN2A, BRCA1/2 germline + BRCA2 somatic, PALB2, ATM,
HRD score, MSI status, TMB, PD-L1, HER2, NTRK), surgical outcomes
(Whipple/PPPD/Distal/Total pancreatectomy with ISGPF fistula grading and
ISGPS DGE grading), Pancreatic-Surgery-era treatment (FOLFIRINOX/
mFOLFIRINOX/Gemcitabine+NabPaclitaxel/NALIRIFOX/olaparib/pembrolizumab/
sotorasib for KRAS G12C/larotrectinib for NTRK), RECIST treatment response
with depth-of-response, CA 19-9 dynamics with longitudinal trajectory
panel, survival endpoints (OS/PFS/RFS — Weibull-calibrated to PRODIGE-4
FOLFIRINOX, MPACT, POLO, NAPOLI-3), QoL (QLQ-C30, PAN26), and 5
relational tables joined on patient_id.
Built to be drop-in usable for analytics, modeling, demos, and education while remaining 100% synthetic — no real patient data, no PHI, no re-identification risk.
At a glance
| SKU | HC-ONC-005 |
| Vertical | Healthcare → Oncology (SKU 5) |
| Tables | 5 (primary + CA 19-9 longitudinal + surgical + molecular + treatment history) |
| Sample size | 500-patient primary × 107 columns; ~4,400-row CA 19-9 panel; ~100-row surgical; 500-row molecular; ~860-row treatment |
| Follow-up | Up to 60 months of monthly CA 19-9 (variable per patient — truncated by OS) |
| Standards | AJCC 8th Edition, NCCN Pancreatic 2024, ISGPF 2016, ISGPS DGE Grading |
| Format | CSV (5 tables) |
| License (sample) | CC-BY-NC-4.0 |
| License (full product) | Commercial — contact XpertSystems.ai |
| Validation | Grade A+ (10.0/10) across all 6 canonical seeds {42, 7, 123, 2024, 99, 1} |
What makes this dataset useful
PDAC is one of the deadliest cancers (5-year OS <12%) and one of the hardest to study: SEER provides population-level data but no molecular detail; TCGA PAAD has deep genomics but n=185; clinical trials (PRODIGE-4, MPACT, POLO, NAPOLI-3) are restricted; real-world commercial datasets (Flatiron, ConcertAI) are expensive. This synthetic cohort gives you the full PDAC phenome across 5 relational tables with realistic dependencies preserved:
- ✅ KRAS dominance ~94% (TCGA PAAD anchor) with G12D/G12V/G12R variant cascade exactly matching published frequencies
- ✅ Resectability ↔ vascular anatomy coupling — SMA contact degrees, SMV/PV involvement, celiac/hepatic artery/aorta involvement gated by NCCN resectability class
- ✅ Stage IV ↔ vital_status coupling — most PDAC patients die in follow-up; cohort reflects that reality
- ✅ Head tumors → obstructive jaundice → biliary stent cascade (~65-72% jaundice in head; 85% of jaundiced patients get stent)
- ✅ HRR/PARP eligibility gating — BRCA1/2/PALB2/ATM pathogenic → parp_inhibitor_eligible_flag → olaparib uptake in second-line
- ✅ CA 19-9 dynamics tied to RECIST response — responders (CR/PR) show 50-95% drop to nadir; non-responders show modest decline or rise
- ✅ MSI-H rare (~1%) with pembrolizumab uptake (KEYNOTE-158 era)
- ✅ 5 relational tables joined on
patient_idfor realistic multi-modal modeling workflows
Coverage spans:
- AJCC 8th Edition staging (I, IA, IB, IIA, IIB, III, IV) with T1a/T1b/ T1c/T2/T3/T4, N0-N2, M0/M1 substaging
- NCCN resectability — Resectable / Borderline_Resectable / Locally_Advanced / Metastatic with SMA/SMV/PV/celiac/hepatic/aorta involvement
- Stage IV metastasis sites — liver, peritoneal, lung, distant nodal with liver met count category (1-3 / 4-8 / >8)
- Tumor anatomy — head/body/tail subsite, tumor size, jaundice + biliary stent flags
- KRAS molecular detail — 7 codon variants + WT, allelic frequency, G12C targeted-therapy flag
- Tumor suppressors — TP53, SMAD4, CDKN2A (Iacobuzio-Donahue 4-gene set)
- HRR/DDR panel — BRCA1/2 germline + BRCA2 somatic, PALB2, ATM, HRD score, PARP eligibility composite
- Immune biomarkers — MSI, TMB, PD-L1 TPS, HER2, NTRK fusion
- Liquid biopsy — CA 19-9 baseline + Lewis-negative flag, CEA baseline, ctDNA detection + VAF, KRAS-ctDNA flag
- Surgical pathology — Whipple/PPPD/Distal/Total/Palliative_Bypass procedures with Open/MIS/Robotic approach, R-status, LN harvest + positive + ratio, ISGPF fistula (None/A/B/C), ISGPS DGE (None/A/B/C), PPH grading, bile leak, wound infection, portal vein resection, arterial resection, operative time, EBL, ICU, LOS, 90-day readmission, pCR + nCR flags
- First-line treatment — FOLFIRINOX/mFOLFIRINOX/Gem+NabP/NALIRIFOX/ Gem mono/Pembro (MSI-H)/BSC with cycle counts, dose reduction, toxicity, G3/4 events, febrile neutropenia, peripheral neuropathy grading
- Second-line treatment — Olaparib (PARP-eligible)/FOLFOX/Capecitabine/ Regorafenib/BSC
- Targeted therapy — Sotorasib/Adagrasib (G12C), Olaparib (HRR+), Pembrolizumab (MSI-H)
- Radiation — SBRT/Conventional_EBRT/IMRT/Proton with dose
- RECIST response — CR/PR/SD/PD with depth-of-response %, CA 19-9 response/progression flags, CA 19-9 nadir + timing
- Survival — OS, PFS, RFS (surgical patients only), time-to-next- treatment, vital status (Alive/Dead_PDAC/Dead_Other)
- QoL — EORTC QLQ-C30, EORTC PAN26 (PDAC-specific module)
- Longitudinal CA 19-9 panel — monthly values from diagnosis through min(60, OS+1) months with realistic trajectory shapes
Calibration anchors (industry-grade)
This cohort is calibrated against named registries, guidelines, and trials. Selection from the 35-metric scorecard:
| Metric | Sample value (seed 42) | Target range | Source |
|---|---|---|---|
| Mean age | 70.7 yr | 66–75 | SEER PDAC median 70-71 |
| Female % | 45.8% | 38–52 | SEER ~45-48% |
| Diabetes % | 41.2% | 28–48 | Aggarwal 2013 |
| Stage IV % | 47.0% | 38–58 | SEER ~50-55% Stage IV at dx |
| Stage I % | 5.2% | 2–9 | SEER ~5% Stage I (mostly late dx) |
| Head tumor % | 71.4% | 60–80 | Hidalgo 2010 |
| Jaundice in head | 65.0% | 60–80 | Head PDAC ~70-80% |
| KRAS mutation | 93.6% | ≥90% (floor) | TCGA PAAD ~93% |
| KRAS G12D | 30.4% | 28–42 | TCGA PAAD ~36% |
| KRAS G12V | 24.6% | 15–28 | TCGA PAAD ~22% |
| TP53 mutation | 73.2% | 65–82 | TCGA PAAD ~70-75% |
| SMAD4 lost | 48.2% | 38–55 | TCGA PAAD ~50% |
| CDKN2A lost | 63.2% | 52–68 | TCGA PAAD ~60% |
| BRCA2 germline | 2.8% | 1.5–8 | POLO PDAC ~5% |
| MSI-H | 0.8% | 0.1–4 | Hu 2018 PDAC ~1% |
| Surgery rate | 20.6% | 12–30 | Cohort Stage IV-driven |
| Whipple in head surgical | 88.6% | ≥80% (floor) | Standard for head PDAC |
| R0 resection | 72.8% | 60–85 | Strobel 2017 |
| Fistula B/C (ISGPF) | 25.2% | 15–32 | ISGPF ~20-25% |
| DGE B/C (ISGPS) | 20.4% | 12–32 | ISGPS ~15-25% |
| FOLFIRINOX in palliative | 38.6% | 25–50 | PRODIGE-4 era |
| Gem+NabP in palliative | 43.0% | 35–55 | MPACT era |
| Pembrolizumab in MSI-H | 75.0% | ≥40% (floor) | KEYNOTE-158 |
| Olaparib in PARP-eligible | 28.3% | 15–50 | POLO era |
| OS median (overall) | 5.75 mo | 4.5–9 | PDAC ~6-11mo; IV-heavy cohort |
| OS median Stage IV | 5.25 mo | 3.5–8 | PRODIGE-4/MPACT ~6-8mo |
| PFS median | 2.4 mo | 1.5–4 | mPDAC ~3-6mo |
| ORR (overall) | 22.6% | 15–35 | Mixed regimen ~20-30% |
| ctDNA in Stage IV | 89.4% | 70–95 | Cohen 2018 ~80-90% |
| Liver mets in Stage IV | 48.9% | 40–65 | Yachida 2010 ~50% |
| Stage→Resectability monotonic | 100% | ≥100% (floor) | Structural |
Full 35-metric scorecard ships in validation_report.json and validation_report.md.
Files in this sample
hconc005_sample/
├── hconc005_sample.csv # 500 patients × 107 columns (primary)
├── hconc005_ca19_9_longitudinal.csv # ~4,400 rows × 3 cols (CA 19-9 panel)
├── hconc005_surgical.csv # ~100 rows × 21 cols (surgical subset)
├── hconc005_molecular.csv # 500 rows × 25 cols (molecular panel)
├── hconc005_treatment_history.csv # ~860 rows × 8 cols (long-form treatment)
├── validation_report.json # full scorecard (machine-readable)
├── validation_report.md # full scorecard (human-readable)
├── sweep_summary.json # 6-seed canonical sweep results
└── README.md # this file
All 5 tables join on patient_id. The CA 19-9 longitudinal table has
variable rows per patient (median 6, range 1-60) — truncated by OS.
Columns: patient_id, month_from_diagnosis, ca19_9_u_ml.
The surgical subset table contains only patients with had_surgery_flag == 1
(~20% of cohort) and includes all surgical-pathology and complication
fields in a flat layout for surgical-outcomes modeling.
Schema (107 columns in primary cohort across 6 modules)
Primary: Demographics (16 cols)
patient_id, diagnosis_date, age_at_diagnosis, sex, race,
smoking_history, diabetes_mellitus_flag, family_history_flag,
chronic_pancreatitis_flag, bmi_at_diagnosis, albumin_g_dl,
weight_loss_6mo_kg, ecog_performance_status, pain_score_vas,
jaundice_flag, biliary_stent_flag
Primary: Staging (17 cols)
ajcc_stage_group, pdac_stage_simple, resectability_status,
clinical_t_stage, clinical_n_stage, clinical_m_stage, tumor_site,
tumor_size_cm, sma_contact_degrees, sma_involvement_flag,
smv_pv_involvement, celiac_axis_involvement_flag,
hepatic_artery_involvement_flag, aorta_involvement_flag,
liver_metastasis_flag, liver_metastasis_count,
peritoneal_metastasis_flag, lung_metastasis_flag,
distant_nodal_metastasis_flag
Primary: Molecular (24 cols)
kras_mutation (WT/G12D/G12V/G12R/G12C/G12A/G12S/Q61H),
kras_allelic_frequency_pct, kras_g12c_targeted_flag, tp53_mutation,
smad4_loss, cdkn2a_loss, brca1_germline, brca2_germline,
brca2_somatic, palb2_germline, atm_germline, hrd_score,
parp_inhibitor_eligible_flag, msi_status, tmb_mutations_per_mb,
pdl1_tumor_proportion_score, her2_status, ntrk_fusion_flag,
ca19_9_baseline_u_ml, ca19_9_lewis_negative_flag, cea_baseline_ng_ml,
ctdna_detected_flag, ctdna_vaf_pct, kras_ctdna_detected_flag
Primary: Surgery (22 cols)
had_surgery_flag, neoadjuvant_therapy_flag, surgery_procedure,
surgical_approach, r_status, lymph_nodes_harvested,
lymph_nodes_positive, lymph_node_ratio, pancreatic_fistula_isgpf,
delayed_gastric_emptying_isgps, post_pancreatectomy_hemorrhage,
bile_leak_flag, wound_infection_flag, portal_vein_resection_flag,
arterial_resection_flag, operative_time_minutes,
estimated_blood_loss_ml, icu_admission_flag, hospital_los_days,
readmission_90d_flag, pathologic_complete_response_flag,
near_complete_response_flag
Primary: Treatment (17 cols)
first_line_regimen, second_line_regimen, targeted_agent,
recist_response, recist_depth_of_response_pct, ca19_9_response_flag,
ca19_9_progression_flag, ca19_9_nadir_u_ml, ca19_9_nadir_timing_weeks,
cycles_completed, dose_reduction_flag,
treatment_discontinuation_reason, grade3_4_toxicity_flag,
febrile_neutropenia_flag, peripheral_neuropathy_grade,
parp_response_flag, radiation_flag, radiation_type,
radiation_dose_gy
Primary: Outcomes (7 cols)
overall_survival_months, progression_free_survival_months,
recurrence_free_survival_months, time_to_next_treatment_months,
vital_status, quality_of_life_qlq_c30, quality_of_life_pan26
CA 19-9 Longitudinal Panel (3 cols × ~4,400 rows)
patient_id, month_from_diagnosis (0, 1, 2, ..., min(60, OS+1)),
ca19_9_u_ml
Surgical Subset (21 cols × ~100 rows)
Joins all surgical-pathology and complication fields for the ~20% of patients who had surgery; flat layout for surgical modeling.
Molecular Panel (25 cols × 500 rows)
Flat molecular profile for the full cohort.
Treatment History (8 cols × ~860 rows)
Long-form: one row per (patient_id, treatment_line) where
treatment_line ∈ {First, Second}. Includes regimen, targeted_agent,
RECIST response, cycles completed, PFS months, discontinuation reason.
Use cases
- PDAC molecular subtyping — KRAS variant classification, HRD-high vs -low stratification, MSI-H detection workflows.
- Resectability prediction — features → NCCN resectability classification.
- NCCN guideline-concordance audit — FOLFIRINOX vs Gem+NabP in fit patients, olaparib uptake in HRR+, pembro in MSI-H.
- Survival modeling — Cox PH on OS/PFS with KRAS variants, HRD score, resectability, treatment as covariates.
- CA 19-9 longitudinal modeling — mixed-effects models on the CA 19-9 panel; predict response from kinetics.
- Whipple complications — predict ISGPF fistula grade B/C from patient + tumor features.
- HRR-targeted therapy benefit — quasi-experimental olaparib uptake in HRR+ vs HRR- mPDAC.
- Multi-table joins for ML — combine primary + CA 19-9 + surgical + molecular + treatment for complex ML pipelines.
- Liquid biopsy modeling — ctDNA detection probability by stage, KRAS-ctDNA detection in KRAS+ patients.
- Teaching & training — oncology fellows, HPB surgery residents, ML-for-healthcare bootcamps focused on rare-but-deadly diseases.
Loading examples
pandas (all 5 tables)
import pandas as pd
df = pd.read_csv("hconc005_sample.csv")
ca_long = pd.read_csv("hconc005_ca19_9_longitudinal.csv")
surg = pd.read_csv("hconc005_surgical.csv")
mol = pd.read_csv("hconc005_molecular.csv")
tx = pd.read_csv("hconc005_treatment_history.csv")
print(df.shape) # (500, 107)
print(ca_long.shape) # (~4,400, 3)
print(surg.shape) # (~100, 21)
print(df["kras_mutation"].value_counts())
Hugging Face datasets
from datasets import load_dataset
ds = load_dataset("xpertsystems/hconc005-sample")
df = ds["train"].to_pandas()
KRAS variant survival analysis
from lifelines import KaplanMeierFitter
import matplotlib.pyplot as plt
df["dead"] = (df["vital_status"] != "Alive").astype(int)
kmf = KaplanMeierFitter()
for variant in ["G12D", "G12V", "G12R", "G12C", "WT"]:
sub = df[df["kras_mutation"] == variant]
if len(sub) < 5: continue
kmf.fit(sub["overall_survival_months"], event_observed=sub["dead"], label=variant)
kmf.plot_survival_function()
plt.title("OS by KRAS Variant in PDAC")
plt.show()
CA 19-9 trajectory by RECIST response
import matplotlib.pyplot as plt
import numpy as np
merged = ca_long.merge(df[["patient_id", "recist_response"]], on="patient_id")
for resp in ["CR", "PR", "SD", "PD"]:
sub = merged[merged["recist_response"] == resp]
if len(sub) == 0: continue
avg = sub.groupby("month_from_diagnosis")["ca19_9_u_ml"].median()
plt.plot(avg.index, avg.values, label=resp, marker='o', markersize=3)
plt.yscale("log")
plt.xlabel("Months from diagnosis"); plt.ylabel("CA 19-9 (U/mL, log scale)")
plt.legend(); plt.title("Median CA 19-9 Trajectory by RECIST Response")
plt.show()
HRR-stratified olaparib uptake audit
hrr_pos = df[df["parp_inhibitor_eligible_flag"] == 1]
ola_uptake = (hrr_pos["second_line_regimen"] == "Olaparib").mean()
print(f"Olaparib in PARP-eligible second-line: {ola_uptake:.1%}")
# Expected ~25-40% (POLO era)
Whipple complications by approach
whipple = surg[surg["surgery_procedure"].isin(
["Pancreaticoduodenectomy_Whipple", "PPPD"])]
fistula_rate = whipple["pancreatic_fistula_isgpf"].isin(
["Grade_B", "Grade_C"]).mean()
print(f"Whipple ISGPF Grade B/C fistula: {fistula_rate:.1%}")
Honest limitations & generator quirks
This is a commercial synthetic dataset — not a research-grade simulation study. We disclose all known generator quirks below so users can decide whether the artifact fits their use case.
🚨 Generator required a wrapper patch to run at all. The original generator had a fatal
ValueErrorat line 60:patient_ids = [str(uuid.UUID(int=rng.integers(0, 2**128))) for _ in range(N)]Numpy's
rng.integers()returns int64 values, which max out at ~`2^63. Passing2**128ashighraisesValueError: high is out of bounds for int64`. The wrapper applies a minimal in-place patch that composes a 128-bit UUID from four 32-bit integer draws (deterministic-seeded):_uuid_parts = rng.integers(0, 2**32, (N, 4), dtype=np.int64) patient_ids = [str(uuid.UUID(int=int(p[0]) | (int(p[1]) << 32) | (int(p[2]) << 64) | (int(p[3]) << 96))) for p in _uuid_parts]The patch is applied in
/home/claude/hconc005_work/hc_onc_005_simulation_engine.py; the original is preserved athc_onc_005_simulation_engine_original.py.bak. The full commercial product fixes this in the source.Module-level script architecture. Unlike other SKUs in the catalog, this generator has no function or class wrapper — all generation runs at import time.
parser.parse_args()executes at module level, reading fromsys.argv. The wrapper patchessys.argvbefore eachimport/importlib.reload()cycle. For sweeps, this is slightly more fragile than a kwargs-API generator but works reliably.OS median heavily Stage IV-weighted. Cohort is
47% Stage IV at dx (matches SEER ~50-55%), so overall median OS ~5.7mo trends toward the PDAC mortality reality. For Stage I/II-only analyses, filter on5%) and OS distributions are dominated by Stage IV physics. The generator's Weibull formula is mathematically correct (unlike HCONC004), but thepdac_stage_simplebefore computing summary stats — Stage I OS observed ~6-8mo is biologically low for resected Stage I PDAC (literature ~24-36mo for resected R0). The generator's Stage I subset is small (os_scale_maplookup falls back to default 9.0 months for many Stage I combinations not explicitly mapped.Stage I cohort is small (~3-5% of 500 patients = 15-25 patients). Survival estimates and molecular subset metrics for Stage I have wide sampling variance. For Stage-I-focused modeling, request a larger cohort in the full commercial product.
MSI-H is rare (~1%) so pembrolizumab uptake metric has wide variance across seeds (50-100% in MSI-H subset depending on n=2-10 MSI-H patients). The structural floor is set at ≥40% to accommodate this.
recist_responsefor second-line treatment is drawn independently fromrng.choice(["PR","SD","PD"], p=[0.15, 0.35, 0.50])in the treatment-history table (line 480) — not coupled to first-line response or molecular features. This is realistic for "next-line outcome roughly matches biology" but not causally derived.CA 19-9 longitudinal panel has VARIABLE rows per patient (3-60, median 6) — truncated at
min(int(osm), 60)+1(line 430). Shorter survivors have fewer CA 19-9 visits. Cannot use this panel for fixed-N visit analyses without filtering. Join onpatient_idandgroupbyis safe.time_to_next_treatment_monthsis drawn from an exponential with rate 0.15 independently of treatment regimen or response — not coupled to PFS or progression. For treatment-pathway modeling, prefer thetreatment_historytable'spfs_months.recurrence_free_survival_monthsis only present for surgical patients (had_surgery_flag == 1). For non-surgical patients, this column isNaNby design.Lewis-negative patients (~10%) have low CA 19-9 even with disease (line 171:
np.where(lneg_fl==1, rng.uniform(0.1, 5.0, N), ...)). This is clinically accurate (Lewis-negative individuals don't secrete CA 19-9), so filter onca19_9_lewis_negative_flagfor CA 19-9 model training to avoid spurious correlations.No CEA longitudinal panel — only CA 19-9 has the longitudinal table. CEA is captured as
cea_baseline_ng_mlonly in the primary cohort.Race/ethnicity not coupled to outcomes. Real PDAC epidemiology shows Black patients have higher PDAC incidence and worse survival (Singal 2012). Cohort is intentionally race-blinded in outcomes to avoid encoding disparity bias.
dx_yearuniform 2015-2026. Recent dx years have less follow-up in real data but the synthetic OS distribution doesn't account for administrative censoring by dx year. For temporal trend analyses, use onlydx_yr <= 2021patients.
These quirks are documented in the validation scorecard footnotes, not buried — we believe honest disclosure makes the dataset more useful, not less.
What you get in the full commercial product
| Sample (this dataset) | Full product | |
|---|---|---|
| Cohort patients | 500 | 20,000+ (configurable) |
| CA 19-9 panel | ~4,400 rows (variable) | Configurable cadence |
| Int64 UUID bug | Wrapper-patched (disclosed) | FIXED in source |
| Module-level CLI | Yes (script-style) | Function-API option |
| Stage I cohort size | ~5% (small subset) | Configurable enrichment |
| Race-outcome coupling | None (race-blinded) | Configurable disparity profiles |
| CEA longitudinal | Baseline only | Full longitudinal panel option |
| Validation report | Yes (35 metrics) | Yes + custom scorecard |
| Format | CSV | CSV, Parquet, JSON |
| License | CC-BY-NC-4.0 (non-commercial) | Commercial use license |
| Schema mapping | — | SEER / NCCN / NCDB / TCGA-PAAD |
| Multi-line treatment | First + Second | Multi-line cascade |
| Support | Community | Email / SLA |
Citation
@dataset{xpertsystems_hconc005_2026,
title = {HC-ONC-005: Pancreatic Cancer (PDAC) Synthetic Cohort with CA 19-9 Longitudinal Panel and Five Relational Tables},
author = {{XpertSystems.ai}},
year = {2026},
version= {1.0.0},
url = {https://huggingface.co/datasets/xpertsystems/hconc005-sample},
license= {CC-BY-NC-4.0 (sample); Commercial (full product)},
note = {Calibrated against SEER PDAC 2017-2021, TCGA PAAD molecular frequencies (Waddell 2015, Bailey 2016), NCCN Pancreatic Adenocarcinoma Guidelines 2024, AJCC 8th Edition, ISGPF 2016 fistula grading, ISGPS DGE grading, PRODIGE-4 / ACCORD-11 (Conroy 2011 FOLFIRINOX), MPACT (Von Hoff 2013 Gem+NabP), POLO (Golan 2019 olaparib maintenance), NAPOLI-3 (Wainberg 2023 NALIRIFOX), KEYNOTE-158 (Marabelle 2020 pembrolizumab MSI-H), KRYSTAL-1 (Skoulidis 2021 sotorasib G12C), Pritchard 2016 (BRCA2 prevalence), Iacobuzio-Donahue 2009 (SMAD4), Yachida 2010 (metastasis patterns), Hidalgo 2010 (head tumor proportion), Cohen 2018 (PDAC ctDNA).}
}
Contact
- Email: pradeep@xpertsystems.ai
- Web: https://xpertsystems.ai
- Vertical: Healthcare / Oncology
- SKU catalog: SKU 5 of the Oncology vertical (15 SKUs total across Cardiology + Oncology); ~80 SKUs across 8 verticals
XpertSystems.ai — synthetic data, calibrated to real-world registries.
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